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Cambridge AS & A Level Biology

16.2The roles of genes in determining the phenotype

The roles of genes in determining the phenotype in Cambridge AS & A Level Biology: what the syllabus expects you to know, the learning objectives and how to practise.
Subtopic122 practice questions6 lessons

Learning objectives

What the syllabus expects you to be able to do.

  1. 16.2.1Explain gene, locus, allele, dominant, recessive, codominant, linkage, test cross, F1, F2, phenotype, genotype, homozygous and heterozygous.
  2. 16.2.2Use genetic diagrams and Punnett squares for monohybrid and dihybrid crosses with dominance, codominance, multiple alleles and sex linkage.
  3. 16.2.3Use genetic diagrams for dihybrid crosses with autosomal linkage and epistasis.
  4. 16.2.4Use genetic diagrams to explain and predict test crosses.
  5. 16.2.5Use the chi-squared test (formula provided) to test the significance of differences between observed and expected results.
  6. 16.2.6Explain how genes, proteins and phenotype are related for TYR (albinism), HBB (sickle cell anaemia), F8 (haemophilia) and HTT (Huntington's disease).
  7. 16.2.7Explain how the Le and le alleles affect gibberellin synthesis and stem elongation.

Lessons

  • Autosomal linkage and epistasis

    40 min

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  • Dihybrid inheritance

    40 min

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  • Genes, proteins and phenotype

    30 min

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  • Monohybrid inheritance and genetic diagrams

    40 min

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  • Sex determination and sex linkage

    35 min

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  • The chi-squared test in genetics

    40 min

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Sample question

A sample question on this topic. Answer it, check it, then read the worked answer.

The roles of genes in determining the phenotype: sample question

1 mark

Which is the correct null hypothesis for a chi-squared test on a cross expected to give a 3 : 1 ratio?

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